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KMID : 0605720030090010056
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Journal of the Korean Society of Biological Therapies in Psychiatry
2003 Volume.9 No. 1 p.56 ~ p.60
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Effect of Nizatidine on Olanzapine-Associated Weight Gain in Patients with Schizophrenia
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Abstract
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Objectives : This pilot study was conducted to evaluate the effect of nizatidine on olanzapine-associated weight gain(OAWG) in schizophrenic patients in Korea.
Methods : Ten subjects with OAWCa from outpatients clinic who were diagnosed with schizophrenia and schizophreniform disorder in accordance with DSM-IV criteria. Positive and Negative Syndrome Scale(PANSS) and Brief Psychiatric Rating Scale(BPRS) wer~ measured at baseline, week 4 and week. 8 as were weight and Body Mass Index(BMI). A flexible dose of olanzapine plus fixed 150mg(b.i.d) dose of nizatidine was administered to all patients. Weight and BMI(kg/m2) were recorded at each visit.
Results : A combination of nizatidine resulted in significant reversal of OAWG without worsening the psychopathology. In line with studies of Western populations, an add-on therapy of nizatidine could be an effective option for the control of weight gain in olanzapine-treated patients in Korea.
Conclusion : Our findings call for further evaluation of the effect of this drug on schizophrenics, with randomized placebo-controlled studies, in Asian populations.
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